• admin
• December 22, 2025

Objective

To assess the cost-effectiveness of treatment strategies in inflammatory bowel disease (IBD), accounting for disease progression and treatment sequencing.

Methods

• Developed a hybrid economic model combining a decision tree with a Markov state-transition framework
• Modelled key disease states, including active disease, remission, progression, surgery, and post-surgery phases
• Explicitly represented induction and maintenance treatment pathways using tunnel states to capture treatment sequencing
• Applied cost inputs and health-state utility values to estimate total costs and quality-adjusted life years (QALYs)

Outcome

The analysis produced decision-grade estimates of costs, QALYs, and cost-effectiveness, supporting early decision making