admin@hevantraObjective To compare the clinical effectiveness of a MET inhibitor for NSCLC with MET exon 14 skipping mutation against relevant comparator treatments using an IPD-based MAIC Methods Conducted an unanchored matching-adjusted indirect comparison (MAIC) in R using individual patient-level
Read Moreadmin@hevantraObjective To assess the cost-effectiveness of treatment strategies in inflammatory bowel disease (IBD), accounting for disease progression and treatment sequencing. Methods Developed a hybrid economic model combining a decision tree with a Markov state-transition framework Modelled key disease states,
Read Moreadmin@hevantraObjective To assess the cost-effectiveness of treatments for locally advanced and metastatic cancer Methods Developed a cohort partitioned survival model informed by published clinical trial data Digitised Kaplan–Meier survival curves to reconstruct patient-level data and fitted appropriate parametric survival
Read Moreadmin@hevantraObjective To generate robust, HTA-ready evidence to support NICE submissions for treatments in gastrointestinal stromal tumors (GISTs) and advanced systemic mastocytosis (AdvSM) Methods Conducted multiple systematic literature reviews (SLRs) in accordance with NICE methods guidance and PRISMA standards. Reviews
Read Moreadmin@hevantraObjective To evaluate and rank the comparative clinical efficacy of targeted therapeutics in prostate cancer using a Bayesian network meta-analysis (NMA) framework Methods Conducted a systematic literature review (SLR) and feasibility assessments to ensure the validity of indirect comparisons
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