admin@hevantra
- December 28, 2025
Objective
To compare the clinical effectiveness of a MET inhibitor for NSCLC with MET exon 14 skipping mutation against relevant comparator treatments using an IPD-based MAIC
Methods
- Conducted an unanchored matching-adjusted indirect comparison (MAIC) in R using individual patient-level data (IPD) from a single clinical trial
- Reweighted IPD to align with published baseline characteristics of comparator studies
- Performed survival analyses on the adjusted dataset, with sensitivity analyses to assess robustness and residual uncertainty
Outcome
Delivered a credible, decision-grade comparative effectiveness assessment to support client decision-making and strategic planning
